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Abstract
Nebivolol is a highly cardio selective β1 -receptor blocker with nitric oxide -potentiating vasodilator effect and used in 50 mg dose for the treatment of the hypertension. Moreover, it is a long-acting antihypertensive agent preferred for treating chronic heart failure in high-risk patients. Transdermal drug delivery systems (TDDS) are adhesive drug-containing devices of defined surface area that deliver a predetermined amount of drug to the intact skin at a preprogrammed rate. The biopharmaceu

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