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Abstract
Nicorandil, a particular medication with a dual mode of action, is prescribed to treat angina. A productive experimental design is suggested on the framework of a Central composite design using QbD. As such there is no HPLC method development of Nicorandil using QbD. So, an attempt was made to determine the presence of Nicorandil in bulk drugs and formulations, a novel, sensitive, and stability-indicating reverse-phase high-performance liquid chromatography technique was developed. A chromatogra

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