Archive Issue Details

Archive Issue Details Volume.2 ,Issue . 2

Manuscript Number
IJPRT-2023-07-016

Manuscript Title
A Validated Stability Indicating RP-HPLC Method for Simultaneous Estimation of Acetyl Cysteine and Taurine in API and its Pharmaceutical Dosage Forms

Article Type
Original Research Articles

Author Names

Sujeetkumar Ahire *
Sandhya Ahire
Akash Ingale
Akshata Jain

Abstract
A RP-HPLC method was developed and validated for the simultaneous estimation of Acetyl cysteine and Taurine in tablets. The proposed RP HPLC method utilized a Agilent C18, 4.6×150 mm, 5 µ column, mobile phase comprised of 0.01N KH2PO4 and Methanol in the ratio 60:40 v/v and flow rate 1 ml/min. The retention time for Acetyl cysteine and Taurine were found to be 1.722 min and 2.696 min. The linearity was in the range of 300 – 900 µg/mL (r = 0.999). The percentage recovery was found to be specific,

Keywords .
Acetyl cysteine and Taurine, RP - HPLC, Simultaneous estimation, Method validation and ICH guidelines

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