Archive Issue Details

Archive Issue Details Volume.2 ,Issue . 3

Manuscript Number
IJPRT-2023-09-035

Manuscript Title
Preclinical Models for Screening of Anti-Stress Agents: A Comprehensive Review

Article Type
Review Article

Author Names

Dr. Kanse Vanita *
Kumari Neha
Pillai Komal
Lodh Hitesh
Shevede Anushree
Singh Kajal

Abstract
A stress response is activated when an uncomfortable stimulus is generated from an external environment or from within the organism, this activation leads to stimulation of the hypothalamic region of the brain which further stimulates and activates the pituitary gland, which leads to stimulation of the adrenal glands and release of stress hormones in the blood. This chain activation of the Hypothalamus, pituitary gland, and adrenal glands is the key step in the generation of the stress response.

Keywords .
Stress response, hypothalamus-pituitary-adrenal axis, physical stress, psychological stress, Immobilization stress, neonatal isolation, forced swimming.

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