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Abstract
Quantitative determination of obeticholic acid is simple, quick, sensitive, accurate, precise, and robust. Using a C18 column (4.6mm X 100mm) as the stationary phase, 0.05% OPA (pH 3.7), and Methanol: water (0.05% OPA) 50:50 as the mobile phase, chromatographic separation has been performed at a flow rate of 0.7 ml. The wavelength used for UV detection was 210 nm. Linearity, accuracy, range, and robustness were all within acceptable bounds as per the ICH criteria. The determination of Obeticholi

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